Human Neurofilament (NEFM) activation kit by CRISPRa

SKU GA103164

NEFM CRISPRa kit - CRISPR gene activation of human neurofilament medium

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: NEFM
• Locus ID: 4741
• Components:

  GA103164G1, Neurofilament gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103164G2, Neurofilament gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103164G3, Neurofilament gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001105541, NM_005382
• UniProt ID: P07197
• Synonyms: NEF3; NF-M; NFM
• Summary: Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]