Human Cytokeratin 8 (KRT8) activation kit by CRISPRa

SKU GA102618

KRT8 CRISPRa kit - CRISPR gene activation of human keratin 8

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: KRT8
• Locus ID: 3856
• Components:

  GA102618G1, Cytokeratin 8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102618G2, Cytokeratin 8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102618G3, Cytokeratin 8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001256282, NM_001256293, NM_002273, NR_045962
• UniProt ID: P05787
• Synonyms: CARD2; CK-8; CK8; CYK8; K2C8; K8; KO
• Summary: This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]