Human VEGF Receptor 2 (KDR) activation kit by CRISPRa

SKU GA102564

KDR CRISPRa kit - CRISPR gene activation of human kinase insert domain receptor

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: KDR
• Locus ID: 3791
• Components:

  GA102564G1, VEGF Receptor 2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102564G2, VEGF Receptor 2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102564G3, VEGF Receptor 2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_002253
• UniProt ID: P35968
• Synonyms: CD309; FLK1; VEGFR; VEGFR2
• Summary: Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]