Human HNRPH3 (HNRNPH3) activation kit by CRISPRa

SKU GA102177

HNRNPH3 CRISPRa kit - CRISPR gene activation of human heterogeneous nuclear ribonucleoprotein H3

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: HNRNPH3
• Locus ID: 3189
• Components:

  GA102177G1, HNRPH3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102177G2, HNRPH3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102177G3, HNRPH3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_012207, NM_021644, NM_001322434, NM_001322436, NM_001322437, NM_001322438, NM_001322439, NM_001322440, NM_001322441, NM_001322442, NM_001322443, NM_001322444, NM_001322445, NM_001322446, NM_001322447, NM_001322448, NM_001322449, NM_001322450, NM_001322451, NM_001322452, NM_001322453
• UniProt ID: P31942
• Synonyms: 2H9; HNRPH3
• Summary: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is localized in nuclear bodies of the nucleus. This protein is involved in the splicing process and it also participates in early heat shock-induced splicing arrest by transiently leaving the hnRNP complexes. Several alternatively spliced transcript variants have been noted for this gene, however, not all are fully characterized. [provided by RefSeq, Jul 2008]