Human alpha Defensin 1 (DEFA1) activation kit by CRISPRa

SKU GA101177

DEFA1 CRISPRa kit - CRISPR gene activation of human defensin alpha 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: DEFA1
• Locus ID: 1667
• Components:

  GA101177G1, alpha Defensin 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101177G2, alpha Defensin 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101177G3, alpha Defensin 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_004084
• UniProt ID: P59665
• Synonyms: DEF1; DEFA2; HNP-1; HP-1; HP1; MRS
• Summary: Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation. [provided by RefSeq, Oct 2014]