Human Asialoglycoprotein Receptor 1 (ASGR1) activation kit by CRISPRa

SKU GA100312

ASGR1 CRISPRa kit - CRISPR gene activation of human asialoglycoprotein receptor 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: ASGR1
• Locus ID: 432
• Components:

  GA100312G1, Asialoglycoprotein Receptor 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100312G2, Asialoglycoprotein Receptor 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100312G3, Asialoglycoprotein Receptor 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001197216, NM_001671
• UniProt ID: P07306
• Synonyms: ASGPR; ASGPR1; CLEC4H1; HL-1
• Summary: This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]