Human Serotonin N acetyltransferase (AANAT) activation kit by CRISPRa

SKU GA100008

AANAT CRISPRa kit - CRISPR gene activation of human aralkylamine N-acetyltransferase

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: AANAT
• Locus ID: 15
• Components:

  GA100008G1, Serotonin N acetyltransferase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100008G2, Serotonin N acetyltransferase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100008G3, Serotonin N acetyltransferase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001088, NM_001166579, NR_110548
• UniProt ID: Q16613
• Synonyms: DSPS; SNAT
• Summary: The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]