NRAMP1 (SLC11A1) (NM_000578) Human Tagged ORF Clone Lentiviral Particle

SKU RC219733L1V

Lenti ORF particles, SLC11A1 (Myc-DDK tagged) - Human solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 (SLC11A1), 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Target Symbol: NRAMP1
• Synonyms: LSH; NRAMP; NRAMP1
• Vector: pLenti-C-Myc-DDK
• Mammalian Cell Selection: None
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC219733).
• ACCN: NM_000578
• ORF Size: 1650 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_000578.2, NP_000569.2
• RefSeq Size: 2573 bp
• RefSeq ORF: 1653 bp
• Locus ID: 6556
• UniProt ID: P49279
• Cytogenetics: 2q35
• Domains: Nramp
• Protein Families: Transmembrane
• Protein Pathways: Lysosome
• MW: 59.7 kDa
• Summary: This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]