TNF alpha (TNF) (NM_000594) Human Recombinant Protein

CAT#: TP750007

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Recombinant protein of human Tumor Necrosis Factor-a (TNFa) produced in E. coli.


 Product Datasheet for 'TP750007'

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USD 411.00


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    • 100 ug


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Specifications

Product Data
Description Recombinant protein of human Tumor Necrosis Factor-a (TNFa) produced in E. coli.
Species Human
Expression Host E. coli
Tag Tag Free
Predicted MW 17.5 kDa
Concentration Resuspend the protein to the desired concentration in proper buffer.
Purity >95% as determined by SDS-PAGE and Coomassie blue staining
Buffer Lyophilized from a sterile solution containing 20 mM phosphate buffer, PH7.2.
Bioactivity Determined by the cytolysis of L929 cells in the presence of Actinomycin D. ED50 for this effect is typically 0.19-0.27 ng/ml.
Endotoxin <0.1 EU per 1 µg of the protein by the LAL
Reference Data
RefSeq NP_000585
Locus ID 7124
Refseq Size 1686
Cytogenetics 6p21.33
Refseq ORF 699
Synonyms DIF; TNF-alpha; TNFA; TNFSF2; TNLG1F
Summary This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome, Secreted Protein, Transcription Factors, Transmembrane
Protein Pathways Adipocytokine signaling pathway, Allograft rejection, Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Asthma, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Fc epsilon RI signaling pathway, Graft-versus-host disease, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), MAPK signaling pathway, Natural killer cell mediated cytotoxicity, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, Type I diabetes mellitus, Type II diabetes mellitus

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Frequently bought together (1)
TNF mouse monoclonal antibody, clone OTI1C1 (formerly 1C1)
    • 100 ul

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68 Mouse Clones
HUMAN PROREINS 101