IL6 (NM_000600) Human Recombinant Protein

SKU TP723713

Purified recombinant protein of Human interleukin 6 (interferon, beta 2) (IL6)

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Human IL-6, the region of Pro29-Met212, from gene Accession# NM_000600
• Tag: Tag Free
• Predicted MW: 21 kDa
• Concentration: lot specific
• Purity: Purity is >98%, as determined by Coomassie stained SDS-PAGE.
• Buffer: PBS, pH 7.2, 0.5M NaCl, 10% Glycerol
• Bioactivity: The ED50 is 4-20 pg/ml, corresponding to a specific activity of 0.5-2.5 X10^8 units/mg, determined by a dose dependent stimulation in a 7TD1 cell proliferation assay.
• Endotoxin: Less than 0.01 ng per ug protein as determined by the LAL method
• Storage: Store at -80°C.
• Stability: Unopened vial can be stored between 2°C and 8°C for up to 2 weeks, at -20°C for up to 6 months, or at -70°C or below until the expiration date. Aliquots can be stored between 2°C and 8°C for up to one week and stored at -20°C or colder for up to 3 months. Avoid repeated freeze/thaw cycles.
• Shipping: Dry Ice

Reference Data

• RefSeq: NP_000591
• Locus ID: 3569
• UniProt ID: P05231
• Cytogenetics: 7p15.3
• RefSeq Size: 1201
• RefSeq ORF: 636
• Synonyms: BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2; IFNB2; IL-6
• Summary: This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). [provided by RefSeq, Aug 2020]
• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Graft-versus-host disease, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Jak-STAT signaling pathway, NOD-like receptor signaling pathway, Pathways in cancer, Prion diseases, Toll-like receptor signaling pathway