CD133 (PROM1) (NM_006017) Human Recombinant Protein
$737.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 97 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_006008 |
| Locus ID | 8842 |
| UniProt ID | O43490 |
| Cytogenetics | 4p15.32 |
| RefSeq Size | 3794 |
| RefSeq ORF | 2595 |
| Synonyms | AC133; CD133; CORD12; MCDR2; MSTP061; PROML1; RP41; STGD4 |
| Summary | This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Mar 2009 |
| Protein Categories | CD Markers, Intracellular Proteins, Membrane Proteins, Nervous system Diseases |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Transmembrane |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "CD133" proteins (7)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH321611 | PROM1 MS Standard C13 and N15-labeled recombinant protein (NP_006008) | 10 ug |
$3,360.00
|
|
| PH327854 | PROM1 MS Standard C13 and N15-labeled recombinant protein (NP_001139319) | 10 ug |
$3,360.00
|
|
| LC416886 | Lyophilized PROM1 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC429028 | Lyophilized PROM1 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY416886 | Transient overexpression lysate of prominin 1 (PROM1), transcript variant 1 (as WB positive control) | 100 ug |
$665.00
|
|
| LY429028 | Transient overexpression lysate of prominin 1 (PROM1), transcript variant 2 (as WB positive control) | 100 ug |
$665.00
|
|
| TP327854 | Recombinant protein of human prominin 1 (PROM1), transcript variant 2, 20 µg | 20 ug |
$737.00
|
|
Citations
Functional links between gelatinase B/matrix metalloproteinase-9 and prominin-1/CD133 in diabetic retinal vasculopathy and neuropathy
Mohammad, Vandooren, Siddiquei et al
Prog Retin Eye Res (2014)
Mohammad, Vandooren, Siddiquei et al
Prog Retin Eye Res (2014)
Cited by 24
AI Summary: OriGene’s recombinant human prominin-1/CD133 protein was used in this study to demonstrate that MMP-9 specifically degrades prominin-1/CD133 in vitro, supporting the mechanistic link between MMP-9 activity and diabetic retinal neuropathy.
Snippet: Recombinant human prominin-1/CD133 (OriGene Technologies) was reacted with recombinant active human MMP-2 or MMP-9. Activation of the pro-enzymes was done with, respectively, APMA or the catalytic segment of MMP-3 and activation of the enzyme was checked by SDS-PAGE (shift in molecular weight). …
Showing 1-1 of 1 papers.
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complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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