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p73 (TP73) (NM_005427) Human Recombinant Protein

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SKU
TP320864
Recombinant protein of human tumor protein p73 (TP73), transcript variant 1, 20 µg
Size:
20 ug 1 mg 100 ug
  $867.00
In Stock*
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Specifications
Specifications
Product Data
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence
Protein Sequence
>RC220864 representing NM_005427
Red=Cloning site Green=Tags(s)

MAQSTATSPDGGTTFEHLWSSLEPDSTYFDLPQSSRGNNEVVGGTDSSMDVFHLEGMTTSVMAQFNLLSS
TMDQMSSRAASASPYTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSA
TWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTAIRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAP
ASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIITLEMR
DGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHG
DEDTYYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPSHLQPPSYGPVLSPMNKVHGG
MNKLPSVNQLVGQPPPHSSAATPNLGPVGPGMLNNHGHAVPANGEMSSSHSAQSMVSGSHCTPPPPYHAD
PSLVSFLTGLGCPNCIEYFTSQGLQSIYHLQNLTIEDLGALKIPEQYRMTIWRGLQDLKQGHDYSTAQQL
LRSSNAATISIGGSGELQRQRVMEAVHFRVRHTITIPNRGGPGGGPDEWADFGFDLPDCKARKQPIKEEF
TEAEIH

TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag C-Myc/DDK
Predicted MW 69.4 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_005418
Locus ID 7161
UniProt ID O15350
Cytogenetics 1p36.32
RefSeq Size 2234
RefSeq ORF 1908
Synonyms P73
Summary This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. provided by RefSeq, Feb 2011
Protein Categories Intracellular Proteins, Transciption Factors
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Neurotrophin signaling pathway, p53 signaling pathway
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Other "p73" proteins (7)
SKU Description Size Price
PH320864 TP73 MS Standard C13 and N15-labeled recombinant protein (NP_005418) 10 ug
$3,360.00
PH325696 TP73 MS Standard C13 and N15-labeled recombinant protein (NP_001119714) 10 ug
$3,360.00
LC417321 Lyophilized TP73 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LC426670 Lyophilized TP73 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY417321 Transient overexpression lysate of tumor protein p73 (TP73), transcript variant 1 (as WB positive control) 100 ug
$665.00
LY426670 Transient overexpression lysate of tumor protein p73 (TP73), transcript variant 4 (as WB positive control) 100 ug
$436.00
TP325696 Purified recombinant protein of Homo sapiens tumor protein p73 (TP73), transcript variant 4, 20 µg 20 ug
$867.00

file-alt Citations

Nucleosome-binding by TP53, TP63, and TP73 is determined by the composition, accessibility, and helical orientation of their binding sites
Wilson, Yu, Buck
bioRxiv (2024)
Snippet: Protein-nucleosome binding assays were performed by incubating the abovementioned purified 305 Pioneer-seq nucleosome library with human TP53α (Abcam ab84768), TAp63α (Origene 306 TP710041), or TAp73α (Origene TP320864) in 7 μl DNA-binding buffer (10 mM Tris-Cl (pH 7.5), 307 50 nM NaCl, 1 mM DTT, 0.25 mg/ml BSA, 2 mM MgCl2, 0.025% Nonidet P-40, and 5% glycerol) 308 for 10 minutes on ice and then 30 minutes at room temperature. …
Showing 1-1 of 1 papers.
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