Mouse Ripor2 activation kit by CRISPRa

SKU GA212747

Ripor2 CRISPRa kit - CRISPR gene activation of mouse RHO family interacting cell polarization regulator 2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Ripor2
• Locus ID: 193385
• Components:

  GA212747G1, Ripor2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA212747G2, Ripor2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA212747G3, Ripor2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001080381, NM_001286100, NM_001286101, NM_029679, NM_178658
• UniProt ID: Q80U16
• Synonyms: 1700108N18Rik; 6330500D04Rik; AI225904; E430013J17Rik; RP23-461O24.1
• Summary: Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization (PubMed:25588844, PubMed:27269051). Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation (PubMed:17150207). Maintains naive T lymphocytes in a quiescent state and prevents chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration (By similarity). Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion (PubMed:25588844). Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear (PubMed:27269051). Plays a role for maintaining the structural organization of the basal domain of stereocilia (PubMed:27269051). Involved in mechanosensory hair cell function (PubMed:27269051). Required for normal hearing (PubMed:27269051).[UniProtKB/Swiss-Prot Function]