Mouse Tbl1xr1 activation kit by CRISPRa

SKU GA211175

Tbl1xr1 CRISPRa kit - CRISPR gene activation of mouse transducin (beta)-like 1X-linked receptor 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Tbl1xr1
• Locus ID: 81004
• Components:

  GA211175G1, Tbl1xr1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA211175G2, Tbl1xr1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA211175G3, Tbl1xr1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_030732
• UniProt ID: Q8BHJ5
• Synonyms: 8030499H02Rik; A630076E03Rik; AW539987; C21; C230089I12Rik; DC42; Ira1; TBLR1
• Summary: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation (By similarity).[UniProtKB/Swiss-Prot Function]