Mouse Sfmbt1 activation kit by CRISPRa

SKU GA205753

Sfmbt1 CRISPRa kit - CRISPR gene activation of mouse Scm-like with four mbt domains 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Sfmbt1
• Locus ID: 54650
• Components:

  GA205753G1, Sfmbt1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA205753G2, Sfmbt1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA205753G3, Sfmbt1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001166531, NM_001166532, NM_019460
• UniProt ID: Q9JMD1
• Synonyms: 4930442N21Rik; 9330180L21Rik; AA536974; Sfmbt; Smr
• Summary: Histone-binding protein, which is part of various corepressor complexes. Mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. Plays a role during myogenesis: required for the maintenance of undifferentiated states of myogenic progenitor cells via interaction with MYOD1. Interaction with MYOD1 leads to the recruitment of associated corepressors and silencing of MYOD1 target genes. Part of the SLC complex in germ cells, where it may play a role during spermatogenesis.[UniProtKB/Swiss-Prot Function]