Human Synaptotagmin 14 (SYT14) activation kit by CRISPRa

SKU GA116841

SYT14 CRISPRa kit - CRISPR gene activation of human synaptotagmin 14

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: SYT14
• Locus ID: 255928
• Components:

  GA116841G1, Synaptotagmin 14 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA116841G2, Synaptotagmin 14 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA116841G3, Synaptotagmin 14 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001146261, NM_001146262, NM_001146264, NM_001256006, NM_153262, NR_027458, NR_027459
• UniProt ID: Q8NB59
• Synonyms: SCAR11; sytXIV
• Summary: This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate membrane trafficking in synaptic transmission. The encoded protein is a calcium-independent synaptotagmin. Mutations in this gene are a cause of autosomal recessive spinocerebellar ataxia-11 (SCAR11), and a t(1;3) translocation of this gene has been associated with neurodevelopmental abnormalities. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Dec 2011]