Human FAM123A (AMER2) activation kit by CRISPRa

SKU GA116472

AMER2 CRISPRa kit - CRISPR gene activation of human APC membrane recruitment protein 2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: AMER2
• Locus ID: 219287
• Components:

  GA116472G1, FAM123A gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA116472G2, FAM123A gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA116472G3, FAM123A gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_152704, NM_199138
• UniProt ID: Q8N7J2
• Synonyms: FAM123A
• Summary: Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex.[UniProtKB/Swiss-Prot Function]