Human Coiled coil domain containing protein 111 (PRIMPOL) activation kit by CRISPRa

SKU GA116411

PRIMPOL CRISPRa kit - CRISPR gene activation of human primase and DNA directed polymerase

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: PRIMPOL
• Locus ID: 201973
• Components:

  GA116411G1, Coiled coil domain containing protein 111 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA116411G2, Coiled coil domain containing protein 111 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA116411G3, Coiled coil domain containing protein 111 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001300767, NM_001300768, NM_001345891, NM_001345892, NM_001345893, NM_001345894, NM_001345895, NM_001345896, NM_001345897, NM_001345898, NM_001345899, NM_001345900, NM_001345901, NM_152683, NR_144312, NR_144313, NR_144314
• UniProt ID: Q96LW4
• Synonyms: CCDC111; MYP22; Primpol1
• Summary: This gene encodes a DNA primase-polymerase that belongs to a superfamily of archaeao-eukaryotic primases. Members of this family have primase activity, catalyzing the synthesis of short RNA primers that serve as starting points for DNA synthesis, as well as DNA polymerase activity. The encoded protein facilitates DNA damage tolerance by mediating uninterrupted fork progression after UV irradiation and reinitiating DNA synthesis. An allelic variant in this gene is associated with myopia 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]