Human POLR3H activation kit by CRISPRa

SKU GA116248

POLR3H CRISPRa kit - CRISPR gene activation of human RNA polymerase III subunit H

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: POLR3H
• Locus ID: 171568
• Components:

  GA116248G1, POLR3H gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA116248G2, POLR3H gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA116248G3, POLR3H gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001018050, NM_001018051, NM_001018052, NM_001282884, NM_001282885, NM_138338
• UniProt ID: Q9Y535
• Synonyms: RPC8; RPC22.9
• Summary: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).[UniProtKB/Swiss-Prot Function]