Human Synaptopodin 2 (SYNPO2) activation kit by CRISPRa

SKU GA116236

SYNPO2 CRISPRa kit - CRISPR gene activation of human synaptopodin 2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: SYNPO2
• Locus ID: 171024
• Components:

  GA116236G1, Synaptopodin 2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA116236G2, Synaptopodin 2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA116236G3, Synaptopodin 2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001128933, NM_001128934, NM_001286754, NM_001286755, NM_133477
• UniProt ID: Q9UMS6
• Synonyms: DKFZp686G051
• Summary: Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:24005909, PubMed:23225103). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336).[UniProtKB/Swiss-Prot Function]