Human TXNDC (TMX1) activation kit by CRISPRa

SKU GA113053

TMX1 CRISPRa kit - CRISPR gene activation of human thioredoxin related transmembrane protein 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: TMX1
• Locus ID: 81542
• Components:

  GA113053G1, TXNDC gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA113053G2, TXNDC gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA113053G3, TXNDC gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_030755
• UniProt ID: Q9H3N1
• Synonyms: PDIA11; TMX; TXNDC; TXNDC1
• Summary: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and one transmembrane domain. Unlike most members of this gene family, it lacks a C-terminal ER-retention sequence. The mature membrane-bound protein can both oxidize and reduce disulfide bonds and acts selectively on membrane-associated polypeptides. [provided by RefSeq, Jan 2017]