Human FLJ14213 (PRR5L) activation kit by CRISPRa

SKU GA112717

PRR5L CRISPRa kit - CRISPR gene activation of human proline rich 5 like

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: PRR5L
• Locus ID: 79899
• Components:

  GA112717G1, FLJ14213 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA112717G2, FLJ14213 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA112717G3, FLJ14213 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001160167, NM_001160168, NM_001160169, NM_024841
• UniProt ID: Q6MZQ0
• Synonyms: PROTOR2
• Summary: Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton (PubMed:17461779). Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration (PubMed:22609986). Plays a role in the stimulation of ZFP36-mediated mRNA decay of several ZFP36-associated mRNAs, such as TNF-alpha and GM-CSF, in response to stress (PubMed:21964062). Required for ZFP36 localization to cytoplasmic stress granule (SG) and P-body (PB) in response to stress (PubMed:21964062).[UniProtKB/Swiss-Prot Function]