Human Ketosamine 3 kinase (FN3KRP) activation kit by CRISPRa

SKU GA112537

FN3KRP CRISPRa kit - CRISPR gene activation of human fructosamine 3 kinase related protein

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: FN3KRP
• Locus ID: 79672
• Components:

  GA112537G1, Ketosamine 3 kinase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA112537G2, Ketosamine 3 kinase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA112537G3, Ketosamine 3 kinase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_024619, NR_046408
• UniProt ID: Q9HA64
• Synonyms: FN3KL
• Summary: A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of psicosamines and ribulosamines compared to the neighboring gene which encodes a highly similar enzyme, fructosamine-3-kinase, which has different substrate specificity. The activity of both enzymes may result in deglycation of proteins to restore their function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]