Human Translation factor GUF1, mitochondrial (GUF1) activation kit by CRISPRa

SKU GA111869

GUF1 CRISPRa kit - CRISPR gene activation of human GUF1 homolog, GTPase

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: GUF1
• Locus ID: 60558
• Components:

  GA111869G1, Translation factor GUF1, mitochondrial gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA111869G2, Translation factor GUF1, mitochondrial gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA111869G3, Translation factor GUF1, mitochondrial gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001345867, NM_001345868, NM_001345869, NM_021927
• UniProt ID: Q8N442
• Synonyms: EF-4; EF4; EIEE40
• Summary: This gene encodes a GTPase that triggers back-translocation of the elongating ribosome during mitochondrial protein synthesis. The protein contains a highly conserved C-terminal domain not found in other GTPases that facilitates tRNA binding. The encoded protein is thought to prevent misincorporation of amino acids in stressful, suboptimal conditions. An allelic variant in this gene has been associated with early infantile epileptic encephalopathy-40. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]