Human KTEL1 (POGLUT1) activation kit by CRISPRa

SKU GA111317

POGLUT1 CRISPRa kit - CRISPR gene activation of human protein O-glucosyltransferase 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: POGLUT1
• Locus ID: 56983
• Components:

  GA111317G1, KTEL1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA111317G2, KTEL1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA111317G3, KTEL1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_020231, NM_152305, NR_024265
• UniProt ID: Q8NBL1
• Synonyms: C3orf9; CLP46; hCLP46; KDELCL1; MDS010; MDSRP; MGC32995
• Summary: This gene encodes a protein with both O-glucosyltransferase and O-xylosyltransferase activity which localizes to the lumen of the endoplasmic reticulum. This protein has a carboxy-terminal KTEL motif which is predicted to function as an endoplasmic reticulum retention signal. This gene is an essential regulator of Notch signalling and likely plays a role in cell fate and tissue formation during development. It may also play a role in the pathogenesis of leukemia. Mutations in this gene have been associated with the autosomal dominant genodermatosis Dowling-Degos disease 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]