Human Histone H2A.J (H2AFJ) activation kit by CRISPRa

SKU GA110952

H2AFJ CRISPRa kit - CRISPR gene activation of human H2A histone family member J

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: H2AJ
• Locus ID: 55766
• Components:

  GA110952G1, Histone H2A.J gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA110952G2, Histone H2A.J gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA110952G3, Histone H2A.J gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_018267, NM_177925, NR_027716
• UniProt ID: Q9BTM1
• Synonyms: FLJ10903; H2A histone family, member J; MGC921; MGC921, FLJ10903
• Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is located on chromosome 12 and encodes a replication-independent histone that is a variant H2A histone. The protein is divergent at the C-terminus compared to the consensus H2A histone family member. This gene also encodes an antimicrobial peptide with antibacterial and antifungal activity.[provided by RefSeq, Oct 2015]