Human VPS35 activation kit by CRISPRa

CAT#: GA110924

VPS35 CRISPRa kit - CRISPR gene activation of human VPS35 retromer complex component

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: VPS35
• Locus ID: 55737
• Kit Components:

  GA110924G1, VPS35 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA110924G2, VPS35 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA110924G3, VPS35 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_018206
• UniProt ID: Q96QK1
• Synonyms: MEM3; PARK17
• Summary: This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq, Jul 2008]