Human Aminoadipate aminotransferase (AADAT) activation kit by CRISPRa

SKU GA109619

AADAT CRISPRa kit - CRISPR gene activation of human aminoadipate aminotransferase

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: AADAT
• Locus ID: 51166
• Components:

  GA109619G1, Aminoadipate aminotransferase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA109619G2, Aminoadipate aminotransferase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA109619G3, Aminoadipate aminotransferase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001286682, NM_001286683, NM_016228, NM_182662
• UniProt ID: Q8N5Z0
• Synonyms: KAT2; KATII; KYAT2
• Summary: This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]