Human D4S234E (NSG1) activation kit by CRISPRa

SKU GA108986

NSG1 CRISPRa kit - CRISPR gene activation of human neuronal vesicle trafficking associated 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: NSG1
• Locus ID: 27065
• Components:

  GA108986G1, D4S234E gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA108986G2, D4S234E gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA108986G3, D4S234E gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001040101, NM_001287763, NM_001287764, NM_014392
• UniProt ID: P42857
• Synonyms: D4S234; D4S234E; NEEP21; P21
• Summary: Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse (By similarity). Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome (By similarity). In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage (PubMed:20599942, PubMed:20878061).[UniProtKB/Swiss-Prot Function]