Human Calpain 7 (CAPN7) activation kit by CRISPRa

SKU GA108330

CAPN7 CRISPRa kit - CRISPR gene activation of human calpain 7

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: CAPN7
• Locus ID: 23473
• Components:

  GA108330G1, Calpain 7 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA108330G2, Calpain 7 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA108330G3, Calpain 7 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_014296
• UniProt ID: Q9Y6W3
• Synonyms: CALPAIN7; PALBH
• Summary: Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The function of the protein encoded by this gene is not known. An orthologue has been found in mouse but it seems to diverge from other family members. The mouse orthologue is thought to be calcium independent with protease activity. [provided by RefSeq, Jul 2008]