Human ASPP1 (PPP1R13B) activation kit by CRISPRa

SKU GA108255

PPP1R13B CRISPRa kit - CRISPR gene activation of human protein phosphatase 1 regulatory subunit 13B

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: PPP1R13B
• Locus ID: 23368
• Components:

  GA108255G1, ASPP1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA108255G2, ASPP1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA108255G3, ASPP1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_015316
• UniProt ID: Q96KQ4
• Synonyms: ASPP1; p53BP2-like; p85
• Summary: This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008]