Human Semaphorin 4D (SEMA4D) activation kit by CRISPRa

SKU GA107177

SEMA4D CRISPRa kit - CRISPR gene activation of human semaphorin 4D

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: SEMA4D
• Locus ID: 10507
• Components:

  GA107177G1, Semaphorin 4D gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA107177G2, Semaphorin 4D gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA107177G3, Semaphorin 4D gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001142287, NM_006378
• UniProt ID: Q92854
• Synonyms: C9orf164; CD100; coll-4; M-sema-G; SEMAJ
• Summary: Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569). Promotes the migration of cerebellar granule cells (PubMed:16055703). Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed:8876214). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:16055703).[UniProtKB/Swiss-Prot Function]