Human FIP200 (RB1CC1) activation kit by CRISPRa

SKU GA106618

RB1CC1 CRISPRa kit - CRISPR gene activation of human RB1 inducible coiled-coil 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: RB1CC1
• Locus ID: 9821
• Components:

  GA106618G1, FIP200 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA106618G2, FIP200 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA106618G3, FIP200 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001083617, NM_014781
• UniProt ID: Q8TDY2
• Synonyms: ATG17; CC1; FIP200; PPP1R131
• Summary: The protein encoded by this gene interacts with signaling pathways to coordinately regulate cell growth, cell proliferation, apoptosis, autophagy, and cell migration. This tumor suppressor also enhances retinoblastoma 1 gene expression in cancer cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]