Human NFkB Inducing Kinase NIK (MAP3K14) activation kit by CRISPRa

SKU GA105993

MAP3K14 CRISPRa kit - CRISPR gene activation of human mitogen-activated protein kinase kinase kinase 14

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: MAP3K14
• Locus ID: 9020
• Components:

  GA105993G1, NFkB Inducing Kinase NIK gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105993G2, NFkB Inducing Kinase NIK gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105993G3, NFkB Inducing Kinase NIK gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_003954
• UniProt ID: Q99558
• Synonyms: FTDCR1B; HS; HSNIK; NIK
• Summary: This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008]