Human IKAP (IKBKAP) activation kit by CRISPRa

SKU GA105634

ELP1 CRISPRa kit - CRISPR gene activation of human elongator complex protein 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: ELP1
• Locus ID: 8518
• Components:

  GA105634G1, IKAP gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105634G2, IKAP gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105634G3, IKAP gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001318360, NM_003640, NM_001330749
• UniProt ID: O95163
• Synonyms: DYS; ELP1; FD; IKAP; IKI3; TOT1
• Summary: The protein encoded by this gene is a scaffold protein and a regulator for three different kinases involved in proinflammatory signaling. The encoded protein can bind NF-kappa-B-inducing kinase and I-kappa-B kinases through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]