Human Thyrotropin Releasing Hormone (TRH) activation kit by CRISPRa

SKU GA104972

TRH CRISPRa kit - CRISPR gene activation of human thyrotropin releasing hormone

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: TRH
• Locus ID: 7200
• Components:

  GA104972G1, Thyrotropin Releasing Hormone gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104972G2, Thyrotropin Releasing Hormone gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104972G3, Thyrotropin Releasing Hormone gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_007117
• UniProt ID: P20396
• Synonyms: Pro-TRH; TRF
• Summary: This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The human proprotein contains six thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as prolactin. Deficiency of this hormone has been associated with hypothalamic hypothyroidism. [provided by RefSeq, May 2013]