Human Thrombopoietin (THPO) activation kit by CRISPRa

SKU GA104869

THPO CRISPRa kit - CRISPR gene activation of human thrombopoietin

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: THPO
• Locus ID: 7066
• Components:

  GA104869G1, Thrombopoietin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104869G2, Thrombopoietin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104869G3, Thrombopoietin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_000460, NM_001177597, NM_001177598, NM_001289997, NM_001289998, NM_001290003, NM_001290022, NM_001290026, NM_001290027, NM_001290028, NM_199228, NM_199356
• UniProt ID: P40225
• Synonyms: MGDF; MKCSF; ML; MPLLG; THCYT1; TPO
• Summary: Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent. [provided by RefSeq, Feb 2014]