Human Synaptotagmin 1 (SYT1) activation kit by CRISPRa

SKU GA104719

SYT1 CRISPRa kit - CRISPR gene activation of human synaptotagmin 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: SYT1
• Locus ID: 6857
• Components:

  GA104719G1, Synaptotagmin 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104719G2, Synaptotagmin 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104719G3, Synaptotagmin 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001135805, NM_001135806, NM_001291901, NM_005639
• UniProt ID: P21579
• Synonyms: P65; SVP65; SYT
• Summary: The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).[supplied by OMIM, Jul 2010]