Human SRY activation kit by CRISPRa

SKU GA104632

SRY CRISPRa kit - CRISPR gene activation of human sex determining region Y

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: SRY
• Locus ID: 6736
• Components:

  GA104632G1, SRY gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104632G2, SRY gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104632G3, SRY gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_003140
• UniProt ID: Q05066
• Synonyms: SRXX1; SRXY1; TDF; TDY
• Summary: This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome. [provided by RefSeq, Jul 2008]