Human nSMase (SMPD2) activation kit by CRISPRa

SKU GA104523

SMPD2 CRISPRa kit - CRISPR gene activation of human sphingomyelin phosphodiesterase 2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: SMPD2
• Locus ID: 6610
• Components:

  GA104523G1, nSMase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104523G2, nSMase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104523G3, nSMase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_003080
• UniProt ID: O60906
• Synonyms: ISC1; NSMASE; NSMASE1
• Summary: This gene encodes a protein which was initially identified as a sphingomyelinase based on sequence similarity between bacterial sphingomyelinases and a yeast protein. Subsequent studies showed that its biological function is less likely to be as a sphingomyelinase and instead as a lysophospholipase. [provided by RefSeq, Oct 2009]