Human Retinoic Acid Receptor beta (RARB) activation kit by CRISPRa

SKU GA104025

RARB CRISPRa kit - CRISPR gene activation of human retinoic acid receptor beta

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: RARB
• Locus ID: 5915
• Components:

  GA104025G1, Retinoic Acid Receptor beta gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104025G2, Retinoic Acid Receptor beta gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104025G3, Retinoic Acid Receptor beta gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_000965, NM_001290216, NM_001290217, NM_001290266, NM_001290276, NM_001290277, NM_001290300, NM_016152, NR_110892, NR_110893
• UniProt ID: P10826
• Synonyms: HAP; MCOPS12; NR1B2; RARbeta1; RRB2
• Summary: This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq, Mar 2014]