Human AMPK alpha 1 (PRKAA1) activation kit by CRISPRa

SKU GA103754

PRKAA1 CRISPRa kit - CRISPR gene activation of human protein kinase AMP-activated catalytic subunit alpha 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: PRKAA1
• Locus ID: 5562
• Components:

  GA103754G1, AMPK alpha 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103754G2, AMPK alpha 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103754G3, AMPK alpha 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_006251, NM_206907, NM_001355028, NM_001355029, NM_001355034, NM_001355035, NM_001355036, NM_001355037
• UniProt ID: Q13131
• Synonyms: AMPK; AMPKa1
• Summary: The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]