Human mtRNA polymerase (POLRMT) activation kit by CRISPRa

SKU GA103665

POLRMT CRISPRa kit - CRISPR gene activation of human RNA polymerase mitochondrial

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: POLRMT
• Locus ID: 5442
• Components:

  GA103665G1, mtRNA polymerase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103665G2, mtRNA polymerase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103665G3, mtRNA polymerase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_005035
• UniProt ID: O00411
• Synonyms: APOLMT; h-mtRPOL; MTRNAP; MTRPOL
• Summary: This gene encodes a mitochondrial DNA-directed RNA polymerase. The gene product is responsible for mitochondrial gene expression as well as for providing RNA primers for initiation of replication of the mitochondrial genome. Although this polypeptide has the same function as the three nuclear DNA-directed RNA polymerases, it is more closely related to RNA polymerases of phage and mitochondrial polymerases of lower eukaryotes. [provided by RefSeq, Jul 2008]