Human DNA Polymerase beta (POLB) activation kit by CRISPRa

SKU GA103646

POLB CRISPRa kit - CRISPR gene activation of human DNA polymerase beta

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: POLB
• Locus ID: 5423
• Components:

  GA103646G1, DNA Polymerase beta gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103646G2, DNA Polymerase beta gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103646G3, DNA Polymerase beta gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_002690
• UniProt ID: P06746
• Synonyms: MGC125976
• Summary: The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date. [provided by RefSeq, Sep 2011]