Human PIK3C2G activation kit by CRISPRa

SKU GA103553

PIK3C2G CRISPRa kit - CRISPR gene activation of human phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: PIK3C2G
• Locus ID: 5288
• Components:

  GA103553G1, PIK3C2G gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103553G2, PIK3C2G gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103553G3, PIK3C2G gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001288772, NM_001288774, NM_004570
• UniProt ID: O75747
• Synonyms: PI3K-C2-gamma; PI3K-C2GAMMA
• Summary: The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]