Human Pepsin (PGA5) activation kit by CRISPRa

SKU GA103508

PGA5 CRISPRa kit - CRISPR gene activation of human pepsinogen 5, group I (pepsinogen A)

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: PGA5
• Locus ID: 5222
• Components:

  GA103508G1, Pepsin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103508G2, Pepsin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103508G3, Pepsin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_014224
• UniProt ID: P00790
• Synonyms: PGA3; PGA4
• Summary: This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer. [provided by RefSeq, Jul 2015]