Human Ornithine Decarboxylase (ODC1) activation kit by CRISPRa

SKU GA103308

ODC1 CRISPRa kit - CRISPR gene activation of human ornithine decarboxylase 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: ODC1
• Locus ID: 4953
• Components:

  GA103308G1, Ornithine Decarboxylase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103308G2, Ornithine Decarboxylase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103308G3, Ornithine Decarboxylase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001287188, NM_001287189, NM_001287190, NM_002539
• UniProt ID: P11926
• Synonyms: ODC
• Summary: This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2013]