Human Neurturin (NRTN) activation kit by CRISPRa

SKU GA103274

NRTN CRISPRa kit - CRISPR gene activation of human neurturin

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: NRTN
• Locus ID: 4902
• Components:

  GA103274G1, Neurturin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103274G2, Neurturin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103274G3, Neurturin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_004558
• UniProt ID: Q99748
• Synonyms: NTN
• Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease. [provided by RefSeq, Aug 2016]