Human NFAT1 (NFATC2) activation kit by CRISPRa

SKU GA103181

NFATC2 CRISPRa kit - CRISPR gene activation of human nuclear factor of activated T cells 2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: NFATC2
• Locus ID: 4773
• Components:

  GA103181G1, NFAT1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103181G2, NFAT1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103181G3, NFAT1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001136021, NM_001258292, NM_001258294, NM_001258295, NM_001258296, NM_001258297, NM_012340, NM_173091
• UniProt ID: Q13469
• Synonyms: NFAT1; NFATP
• Summary: This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012]