Human Neurofilament (NEFL) activation kit by CRISPRa

SKU GA103167

NEFL CRISPRa kit - CRISPR gene activation of human neurofilament light

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: NEFL
• Locus ID: 4747
• Components:

  GA103167G1, Neurofilament gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103167G2, Neurofilament gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103167G3, Neurofilament gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_006158
• UniProt ID: P07196
• Synonyms: CMT1F; CMT2E; NF-L; NF68; NFL; PPP1R110
• Summary: Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008]